Liver transplantation for primary intrahepatic adenosquamous carcinoma using a marginal graft

Abstract

Author(s): Peng Chen, Di Ma,Ruokun Li, Xiaoqun Yang, Hui Tong, Debin Qi, Tao Li

Background: Primary Intrahepatic Adenosquamous Carcinoma (iASC) is a very rare subtype of Cholangiocarcinoma (CCA), with a worse prognosis than adenocarcinoma. Hepatectomy is still the first choice for iASC, and Liver Transplantation (LT) for iASC has not been previously reported. Case presentation: The young male patient with an unresectable primary iASC underwent a LT using a marginal fatty liver graft. The overall survival of this patient was 16 months, with a recurrence-free survival of 8 months. The patient had a good quality of life with normal liver function until 3 months before death. Conclusions: This is the first case report of LT as treatment of unresectable iASC using a marginal graft, by which our patient gained a longer survival. Although the recipient may benefit from LT, LT for iASC should proceed with caution owing to its more aggressive features. Key words: Case report, cancer/malignancy/neoplasia, primary adenosquamous carcinoma, cholangiocarcinoma, liver transplantation/hepatology

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