Liver transplantation for primary intrahepatic adenosquamous carcinoma using a marginal graft


Author(s): Peng Chen, Di Ma,Ruokun Li, Xiaoqun Yang, Hui Tong, Debin Qi, Tao Li

Background: Primary Intrahepatic Adenosquamous Carcinoma (iASC) is a very rare subtype of Cholangiocarcinoma (CCA), with a worse prognosis than adenocarcinoma. Hepatectomy is still the first choice for iASC, and Liver Transplantation (LT) for iASC has not been previously reported. Case presentation: The young male patient with an unresectable primary iASC underwent a LT using a marginal fatty liver graft. The overall survival of this patient was 16 months, with a recurrence-free survival of 8 months. The patient had a good quality of life with normal liver function until 3 months before death. Conclusions: This is the first case report of LT as treatment of unresectable iASC using a marginal graft, by which our patient gained a longer survival. Although the recipient may benefit from LT, LT for iASC should proceed with caution owing to its more aggressive features. Key words: Case report, cancer/malignancy/neoplasia, primary adenosquamous carcinoma, cholangiocarcinoma, liver transplantation/hepatology

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Editors List


    Submitted PhD thesis in Biotechnology at GITAM University, Vizag.

  • Yousef Alomi

    Yousef Alomi
    The Past Head, General Administration of Pharmaceutical Care at Ministry of Health,
    Saudi Arabia Critical Care/TPN
    Clinical Pharmacist Ministry of Health,
    Riyadh, Saudi Arabia.

  • Osamu Tanaka

    Osamu Tanaka
    Assistant Professor,
    Department of Radiation Oncology
    Asahi University Hospital
    Gifu city, Gifu, Japan

  • Maher Abdel Fattah Al-Shayeb

    Department of Surgical Sciences, Ajman University, UAE

  • Andrzej Zdziennicki

    Institute of Gynecology and Obstetrics, Medical University of Lodz, I Clinic of Gynecology and Gynecological Oncology (Lodz, Poland)

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