Abstract

Author(s): Hrnčár Matej, Breznický Jozef, Chudej Juraj, Sokol Juraj, Staško Ján

Background: The incidence of thrombotic complications in patients with malignancy is higher than in the general population. There is little data about the association of congenital thrombophilia with malignant disease. Methodology: We report a 48 years old patient with inherited thrombophilia (homozygous factor V Leiden and homozygous MTHFR C677T) with the manifestation of thromboembolic disease who developed colorectal carcinoma seventeen years after diagnosis of thrombotic events. Discussion: We discuss the need for cancer screening in patients with inherited thrombophilia as the need for thromboprophylaxis in patients with inherited thrombophilia and cancer. Conclusion: We now have to focus on clinical experience and think about the possibility of cancer in patients with congenital thrombophilia. In case of any suspicion, adequate investigation is needed to detect the early stage of the disease

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