Hyalinizing clear cell carcinoma of tonsil: about a case report and review of the literature


Author(s): Abboud Fatima Zahra, Ait Erraisse Mohamed, Youssoufi Moulay Ali, Zoukal sofia, Bouhafa Touria, Hassouni Khalid

Background: Clear cell carcinoma (CCC) is a low-grade malignant tumor that usually appears in the minor salivary glands of the oropharynx and other sites and is a rare feature of salivary gland tumors. Methods: We present here the case of a 58-year-old woman with no medical history. She consulted for swelling under the left mandible. On clinical examination, the patient had a swelling of the left tonsil. A biopsy was performed and histological and immunohistochemical results were used to diagnose a Hyalinizing clear cell carcinoma of the left tonsil. Cervical facial CT scan showed a tumor process of the left tonsil compartment with bilateral cervical lymphadenopathies. No other lesions were detected in the systemic evaluation. Surgery was not feasible in this patient and therefore the decision to opt for concurrent chemo-radiotherapy was made. Results: The patient was reviewed after 1 month. Clinically, it shows a regression of cervical adenopathies and a decrease in the volume of the tonsillar tumor mass. Skin reactions almost resolved. The patient was doing well. Conclusion: concurrent chemo-radiotherapy is used in the treatment of locally advanced clear-cell carcinoma of the tonsils that escape surgery with good disease control results.

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Editors List

  • Osamu Tanaka

    Osamu Tanaka
    Assistant Professor,
    Department of Radiation Oncology
    Asahi University Hospital
    Gifu city, Gifu, Japan

  • Maher Abdel Fattah Al-Shayeb

    Department of Surgical Sciences, Ajman University, UAE

  • Andrzej Zdziennicki

    Institute of Gynecology and Obstetrics, Medical University of Lodz, I Clinic of Gynecology and Gynecological Oncology (Lodz, Poland)

  • Krzysztof Urbanski

    Head of the Oncology Gynecology Clinic, Oncology Center - Instytut im. Maria Sklodowska Curie, Department in Krakow (Krakow, Poland)

  • Andrzej Szawlowski

    Klinika Nowotworow Gornego Odcinka Uklad Digestii, Oncology Center - Institute (Warsaw, Poland)