Hallmarks of cancer stem cells in men associated cancers: a review

Abstract

Author(s): Sreedhar Surampudi, Satyanarayana Swamy, Satyanarayana Rentala, Sivarama Prasad Darsi

Failure of conventional therapies is the root cause for the progression of the cancer. Intrinsic revelation states that Cancer metastasis is due to subclonal diversification of normal cells into subsets of stem like cells. These cells can be termed as stem cells of the cancer or cells that initiate cancer. These diversified cells can differentially activate and escape from the resistant mechanisms causes tumor heterogeneity. Because of these metastatic fuelling which is malignant, expresses its persistence towards treatment and provokes drug-resistant recurrence. Annihilation of these subsets of stem like cells in cancer tissues has now become a prime objective to develop and design novel classes of anti-cancer therapeutics to improve clinical efficacy. In this review, the properties and hallmark of different cancer stem cells that are responsible for disease recurrence and metastases which are elusive targets for present oncotherapies was presented.

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Editors List

  • Osamu Tanaka

    Osamu Tanaka
    Assistant Professor,
    Department of Radiation Oncology
    Asahi University Hospital
    Gifu city, Gifu, Japan

  • Maher Abdel Fattah Al-Shayeb

    Department of Surgical Sciences, Ajman University, UAE

  • Andrzej Zdziennicki

    Institute of Gynecology and Obstetrics, Medical University of Lodz, I Clinic of Gynecology and Gynecological Oncology (Lodz, Poland)

  • Krzysztof Urbanski

    Head of the Oncology Gynecology Clinic, Oncology Center - Instytut im. Maria Sklodowska Curie, Department in Krakow (Krakow, Poland)

  • Andrzej Szawlowski

    Klinika Nowotworow Gornego Odcinka Uklad Digestii, Oncology Center - Institute (Warsaw, Poland)