Hallmarks of cancer stem cells in men associated cancers: a review
Author(s): Sreedhar Surampudi, Satyanarayana Swamy, Satyanarayana Rentala, Sivarama Prasad Darsi
Failure of conventional therapies is the root cause for the progression of the cancer. Intrinsic revelation states that Cancer metastasis is due to subclonal diversification of normal cells into subsets of stem like cells. These cells can be termed as stem cells of the cancer or cells that initiate cancer. These diversified cells can differentially activate and escape from the resistant mechanisms causes tumor heterogeneity. Because of these metastatic fuelling which is malignant, expresses its persistence towards treatment and provokes drug-resistant recurrence. Annihilation of these subsets of stem like cells in cancer tissues has now become a prime objective to develop and design novel classes of anti-cancer therapeutics to improve clinical efficacy. In this review, the properties and hallmark of different cancer stem cells that are responsible for disease recurrence and metastases which are elusive targets for present oncotherapies was presented.
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Submitted PhD thesis in Biotechnology at GITAM University, Vizag.
The Past Head, General Administration of Pharmaceutical Care at Ministry of Health,
Saudi Arabia Critical Care/TPN
Clinical Pharmacist Ministry of Health,
Riyadh, Saudi Arabia.
Department of Radiation Oncology
Asahi University Hospital
Gifu city, Gifu, Japan
Maher Abdel Fattah Al-Shayeb
Department of Surgical Sciences, Ajman University, UAE
Institute of Gynecology and Obstetrics, Medical University of Lodz, I Clinic of Gynecology and Gynecological Oncology (Lodz, Poland)
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