Genes involved in wound healing: a narrative review

Abstract

Author(s): Reza Akhavan-Sigari

Objective: The repair process of wounds consists of a consecutive interaction of different types of cells, soluble mediators, and Extracellular Matrix (ECM). This study aims to provide a review of genes involved in wound healing. Design: This is a narrative review. Material and Method: Aiming to provide a comprehensive database of genes involved in wound healing a wide range of studies were studied. The most wellknown databases such as PubMed, Medline, Embase, Science Direct, and Scopus were reviewed up. In this regard, a total of 320 articles were collected. Results: Having an appropriate knowledge of the pathophysiology of wound healing provided a more advanced technology to authorize optimization of microenvironments within wounds. During the last decade, different models of gene delivery have been introduced which include viral transfection, and Nonviral techniques. In this regard, TIMP-2 protein, VEGF mutants like VEGF165, HIF-1, and CARP are among the most suitable genes that accelerate the rate of tissue repair. Discussion: The process of wound healing is mainly associated with the increment of expression of genes that has a role in the aspects of inflammation and repair. Conclusion: In our study, most suitable genes involved in the wound healing process are introduced. The repair process of wounds consists of a consecutive interaction of different types of cells, soluble mediators, and Extracellular Matrix (ECM). This study aims to provide a review of genes involved in wound healing.

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