Exploring the relationship among superoxide dismutase, prostate specific antigen, and oxidative stress levels in benign and malignant prostate hyperplasia: Implications for oncology

Abstract

Author(s): Mustafa T ALbaldawy, Alaauldeen SM AL-Sallami, Mohammad Al-zeyadi, Hamid Altameemi*, Ali R Medhat, Dina AA Abdullah, Noor Nayyef Oudah, Shahrazad Ahmed Khalaf, Hussein M Prism

Background: The present study aimed to identify changes in superoxide dismutase and Malondialdehyde (MDA) levels and their relationship to benign and malignant prostate hyperplasia compared to healthy men.

Methods: the samples of study collected at the laboratories of the middle Euphrates hospital. The sample group was taken as follows: 32 samples of prostate cancer patients, 28 samples of benign prostate tumor with 29 samples as a control cases. The serum taken for biochemical tests of Superoxide Dismutase (SOD) and Malondyaldyhide (MDA) was measured by ELISA method.

Results: The current study shows a significant increase (p<0.05) in malondialdehyde level in prostate cancer in compared with the control group, but a non-significant difference was not found between benign prostate hyperplasia and the control group. There was a significant difference (p<0.05) between benign prostate hyperplasia and prostate cancer. In addition, the results had shown a significant decrease (p<0.05) in Superoxide dismutase level in patients with prostate cancer compared with both the healthy group and benign prostate hyperplasia, While non-significant difference (p>0.05) was shown in benign prostate hyperplasia by compare with the health group. Regarding the correlation studies, the present study shown a negative correlation between malondialdehyde and Superoxide dismutase concentrations.

Conclusion: The current study showed a marked decrease in Superoxide dismutase levels while significantly higher malondialdehyde concentration levels in the serum of patients with prostate cancer.

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