Ekspresja neuropiliny-2 w raku jajnika
Author(s): Wieslawa Bednarek, Magdalena Mazurek-Kociubowska, Iwona Wertel
Introduction: Neuropilin-2 (NRP2), a transmembrane receptor, plays an important role in the distribution of lymphatic vessels. Blocking the binding of VEGF-C with neuropilin-2 by using specific antibodies, inhibits in vivo distribution of terminal lymphatic endothelial cells.
Aim: The aim of this study was to determine the expression of neuropilin-2 in ovarian cancer and to evaluate correlations with clinical features.
Material and methods: The material was collected from from 61 patients operated by the reason of ovarian cancer, between the ages of 24 to 82 (Mean 56,31±14,27). On histopathological examination 30 cases of serous carcinoma, 21 mucinous cancer and 10 endometrial cancer were found.
Results: The expression of NRP2 with a strong degree of intensity was found in 7 cases, of low-grade 30 cases. No expression was found in 24 cases. There was no significant correlation between expression of neuropilin-2 and FIGO stage, tumor type or degree of histopathological differentiation.
Conclusion: Considering the results of the study, it is hard to define the role of neuropilin- 2 in lymphangiogenesis in oarian cancer.<
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Prof. Elhadi Miskeen
Obstetrics and Gynaecology Faculty of Medicine, University of Bisha, Saudi Arabia
Ahmed Hussien Alshewered
University of Basrah College of Medicine, Iraq
Department of Electronics and Communication Engineering SRM University – AP, Andhra Pradesh
Supervisor of Biochemistry Lab and PhD. students of Faculty of Science, Department of Chemistry and Department of Chemis
Fava Maria Giovanna
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