Czy odmiana mikroskopowa inwazyjnego zrazikowego raka piersi ma znaczenie prognostyczne?
Author(s): PIOTR SKOTNICKI, JANUSZ RYÃ Â, JERZY JAKUBOWICZ, PAWEÃ Â BLECHARZ
Apart from the classic infiltrating lobular breast carcinoma (ILC) several further varieties have been depicted. Some classifications have wide-spread approval (solid, alveolar, tubulolobular), others are commonly discussed (pleomorphic, histhocyto-like, mixed), others still renounced by many authors (e.g. signet ring cell, trabecular). The incidence of particular ILC variants is difficult to assess in respect of various, from an intense to extreme extent, interpretations of the ILC microscopic image as furnished by different researchers. The majority considers the tubulolobular form as evincing He Best prognosis. The classic, mixed and alveolar forms are attributed an intermediate prognosis. Pleomorphic form exceeds the heretofore mentioned in terms of aggressiveness and the lowest indices of long term survivals were fund In patients with the solid variant of ILC. However, conflicting interpretations of microscopic images, the low numbers of patients in groups examined, inexistence of cases stratification as regards the degree of carcinoma development, finally, the absence of statistic variation of the reported differences in terms of survival rate, jointly result in the controversies over the prognostic significance of microscopic images of ILC.
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Institute of Gynecology and Obstetrics, Medical University of Lodz, I Clinic of Gynecology and Gynecological Oncology (Lodz, Poland)
Head of the Oncology Gynecology Clinic, Oncology Center - Instytut im. Maria Sklodowska Curie, Department in Krakow (Krakow, Poland)
Klinika Nowotworow Gornego Odcinka Uklad Digestii, Oncology Center - Institute (Warsaw, Poland)
Department of Radiotherapy, Oncology Center-Institute (Warsaw, Poland)
Head of the Obstetrics and Gynecology Clinic of the University of Otto von Guericke (Magdeburg, Germany)