Comparison of propofol versus fentanyl infusion for postoperative sedation in mechanically ventilated patients following head and neck oncosurgeries- A Retrospective analytic study.

Abstract

Author(s): Roopesh Sureshan, Sonali Opneja* and Riyas M

Background: Sedation in intensive care patients is assumed to increase tolerance of mechanical ventilation and reduce metabolic demands.

Aim: To determine the efficacy of propofol versus fentanyl infusion for sedation in mechanically ventilated patients following head and neck oncosurgeries.

Settings and Design: A retrospective analytic study was done in a tertiary care cancer centre in patients who had undergone head and neck oncosurgeries and required postoperative ventilation at the ICU and were sedated with either propofol or fentanyl infusion. All patients taken were sedated overnight to achieve Richmond Agitation Sedation Scale Score 0 to -3. RASS score, pulse rate, mean arterial pressure at 2nd hour,4th hour,6th hour and 8th hour was assessed. Patient’s data were retrieved from 01st August 2020 to 31st August 2021.Statistical Analysis were analysed using Student’s t-test and Chi-square test.

Results: Both groups were able to achieve a target RASS between 0 to -3.

The sedation induced by propofol was significantly higher than that induced by fentanyl at 2 hours and 6 hours. There was no significant difference in MAP of both groups. Heart rate at every time point was significantly higher in participants administered fentanyl at 2 hours, 4 hours, 6 hours and 8 hours, respectively. However, in both groups the parameters were within normal limits.

Conclusion: Both fentanyl and propofol are equally efficacious in postoperative sedation without major hemodynamic fluctuations.

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