Clinical and pathological importance of TIGD3 gene expression in colorectal cancer patients

Abstract

Author(s): Ahmed H. Qasim*

Background: Advanced human cancers exhibit significant levels of TIGD3 expression. The purpose of this study was to look at possible associations between positive TIGD3 expression and clinical, pathological aspect in colorectal cancer patients. Methods: In this cross-sectional investigation, TIGD3 expression levels were measured in 100 colorectal cancer tissues using western blot and immunohistochemical labeling. Following that, immunohistochemicalstaining outcomes were contrasted with clinicopathological characteristics. Results: In 82 out of 100 colorectal cancer samples, TIGD3 expression was shown to be present. TIGD3 expression was substantially correlated with higher stages of cancer TNM III-IV (p=000117), lymph vascular invasion (p=000045) and angiovascular invasion (p=00001), in contrast to other clinicopathological criteria. Conclusion: The results of this investigation imply that elevated or positive TIGD3 expression may be linked to an advanced stage and a bad prognosis.

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