Association of monocyte chemoattractant protein-1 with age, glucose, BMI, insulin and other breast cancer biomarkers


Author(s): Jinseog Kim, Rabindra Nath Das, Youngjo Lee, Ranjan Kumar Sahoo

Breast cancer is in most cases noticed over the world as the second cause of cancer-allied death in women. Monocyte chemoattractant protein-1 (MCP1) plays an essential role in the opening and advancement of cancer. The report derives the association of MCP-1 with age, BMI, insulin, glucose and other breast cancer biomarkers such as leptin, resistin, adiponectin, HOMA based on a real data set. It is obtained herein that mean MCP-1 is positively associated with BMI (p<0.0001), resistin (p<0.0001) and the interaction effect of insulin and leptin (i.e., insulin*leptin) (p<0.0001), while it is negatively associated with insulin (p<0.0001) and leptin (p<0.0001). The variance of MCP-1 is positively associated with age*insulin (p=0.0025), leptin*resistin (p=0.0176) and glucose*leptin (p=0.0819), while it is negatively associated with age (p=0.0706), homeostasis model assessment score (HOMA) (p=0.0055), leptin (p=0.0198) and resistin (p=0.0777). Only three partially significant effects (approximately 8% level of significance) are included in the Gamma variance model, while they are significant in the Log-normal variance model. These are accounted as a confounder in the model in view of Epidemiology. It is concluded herein that MCP-1 is higher for women with high BMI, higher levels of resistin, low levels of both insulin and leptin, along with their high interaction effect.

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    Submitted PhD thesis in Biotechnology at GITAM University, Vizag.

  • Yousef Alomi

    Yousef Alomi
    The Past Head, General Administration of Pharmaceutical Care at Ministry of Health,
    Saudi Arabia Critical Care/TPN
    Clinical Pharmacist Ministry of Health,
    Riyadh, Saudi Arabia.

  • Osamu Tanaka

    Osamu Tanaka
    Assistant Professor,
    Department of Radiation Oncology
    Asahi University Hospital
    Gifu city, Gifu, Japan

  • Maher Abdel Fattah Al-Shayeb

    Department of Surgical Sciences, Ajman University, UAE

  • Andrzej Zdziennicki

    Institute of Gynecology and Obstetrics, Medical University of Lodz, I Clinic of Gynecology and Gynecological Oncology (Lodz, Poland)

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