Anti-angiogenic therapy in glioblastoma multiforme

Abstract

Author(s): Paulina Kozakiewicz

Glioblastoma multiforme is the most common brain malignan-cy in adults. It is also highly aggressive and characterized by very poor prognosis. Surgical resection of the tumor remains the basic treatment that significantly improves survival. Moreover, adjuvant chemoradiotherapy is the standard-of-care. Glioblastoma multiforme has a very complex genetic profile; various genetic abnormalities have been discovered in cells of this type of tumor. Despite growing interest in tar-geted therapies in oncology, no breakthrough offering suc-cessful treatment of glioblastoma multiforme has occurred. Owing to the tumor’s rich vasculature, antiangiogentic the-rapies seem promising. An association between carcinogene-sis and tumor vasculature was observed in 1970s. At present, the only FDA-approved drug targeting antiogenesis-stimula-ting factor is bevacizumab. In recent years, more and more new antiangiogenic therapies have been investigated in both monotherapy and combined treatment of glioblastoma mul-tiforme with different success rates. This article presents an overview of the most explored therapies.

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Editors List

  • S.SREEDHAR

    Submitted PhD thesis in Biotechnology at GITAM University, Vizag.

  • Yousef Alomi

    Yousef Alomi
    The Past Head, General Administration of Pharmaceutical Care at Ministry of Health,
    Saudi Arabia Critical Care/TPN
    Clinical Pharmacist Ministry of Health,
    Riyadh, Saudi Arabia.

  • Osamu Tanaka

    Osamu Tanaka
    Assistant Professor,
    Department of Radiation Oncology
    Asahi University Hospital
    Gifu city, Gifu, Japan

  • Maher Abdel Fattah Al-Shayeb

    Department of Surgical Sciences, Ajman University, UAE

  • Andrzej Zdziennicki

    Institute of Gynecology and Obstetrics, Medical University of Lodz, I Clinic of Gynecology and Gynecological Oncology (Lodz, Poland)

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