A study to classify the fine needle aspirates of breast lumps as per the IAC Yokohama system for reporting breast cytopathology along with histopathological correlation

Abstract

Author(s): Jyoti Brahmaiah, S Bhavadeep*, V Hemanth Kumar, Swarnabala Malapaka, T Govardhan and Satyanarayana Rentala

Introduction: The burden of breast cancer is growing all over the world. Fine Needle Aspiration Cytology is an important diagnostic test in the early diagnosis of breast lesions. The IAC Yokohama classification for reporting breast cytopathology cases have five standard categories namely Insufficient (C1), Benign (C2), Atypical (C3) , Suspicious of malignancy (C4) and Malignant (C5).
Aims and Objectives: To classify the breast cytopathology cases as per the IAC Yokohama system of reporting breast cytopathology and to calculate the Risk of Malignancy, Sensitivity, Specificity, Positive Predictive Value, Negative Predictive Value.
Materials and Methods: The cytopathological diagnoses of breast lesions were categorized as per the IAC Yokohama system for reporting breast cytopathology. With histopathology as gold standard, Sensitivity, Specificity, Positive Predictive Value (PPV), Negative Predictive Value (NPV), Risk of Malignancy (ROM) and diagnostic accuracy were also calculated using standard formulae.
Results: A total of 223 cases of FNACs of breast lesions were done in this study of which 105 had histopathological correlation. The number of cases in each IAC Yokohama category are C1 (6), C2 (174), C3(13), C4(8 ),C5(22). The ROM malignancy in each of these categories was C1(0%), C2 (3.84%), C3(55.55%), C4(100%), C5(100%).
Conclusion: FNAC will continue to play an important role in early diagnosis of breast cancers. The IAC Yokohama system of breast cytopathology reporting helps in standardizing the reports of these cases.

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Awards Nomination

Editors List

  • Ahmed Hussien Alshewered

    University of Basrah College of Medicine, Iraq

  • Sudhakar Tummala

    Department of Electronics and Communication Engineering SRM University – AP, Andhra Pradesh

     

     

     

  • Alphonse Laya

    Supervisor of Biochemistry Lab and PhD. students of Faculty of Science, Department of Chemistry and Department of Chemis

     

  • Fava Maria Giovanna

     

  • Manuprasad Avaronnan

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