A Comparative Study of Serum and Salivary Levels of HER2 and ER in Breast Cancer

Abstract

Author(s): Haider M. Barghash Al Musawi, Mayada Noori Iqbal, Mamdooh Abdul RazzaK M. AL- Nasrawi

Circulating Human Epidermal Growth Factor Receptor (HER-2/neu) receptor protein concentrations in breast cancer patients seem to be as helpful as predictive indicators of survival as age, tumor size, Progesterone receptor and Estrogen receptor expression. Estrogen receptor is a protein molecule that specifically binds to estrogen in cells, it is one of the effective tumor markers for breast cancer, and Estrogen receptor has an important role in the cellular growth and differentiation of cells and their proliferation. The current study aims to examine and assess changes in serum and salivary Human Epidermal Growth Factor Receptor (HER2), Estrogen Receptor (ER.) and how they affect breast cancer. A total of 130 females within the ages of 17, 75 underwent tests, with 90 of them constituting a clinical group of women with early-stage breast cancer. Of them, 45 had malignant breast cancer and 45 had benign tumors in their breasts and 40 healthy women they represent the control group disease-free, healthy women and paired samples from women with benign breast illness and women with malignant breast cancer were used to compare the serum and salivary levels of the Human epidermal growth factor receptor and the Estrogen Receptor. The results of this investigation showed a favorable association between the levels of Estrogen Receptor (ER) serum with levels of Human epidermal growth factor receptor salivary and serum with (r=0.720, 0.775 ) these differences statistically were highly significant (p-value=0.000, 0.000) The findings of this study also showed a positive correlation between the levels of Human epidermal growth factor receptor salivary and Human epidermal growth factor receptor serum with (r=0.618) with highly significant differences (pvalue=0.000) among malignant and benign groups. Women with benign and malignant tumors have higher levels of estrogen receptor and human epidermal growth factor receptors in their serum and saliva compared with healthy women. The study demonstrated that saliva samples can be used to investigate immunological indicators of breast cancer.

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