Investigation of BDNF, apoptosis and cholinergic system enzymes in glioblastoma multiforme patient serum

Abstract

Author(s): Sama Amer Abbas El-Tekreti, Asli Çilingir Yeltekin, Abdurrahman Aycan, Abddurrahim TAS

Background: Glioblastoma Multiforme (GBM) is the most common type of brain tumor and it is an aggressive form of adult brain cancer that is globally fatal. Unfortunately, the poor prognosis of patients with glioblastoma and current treatments do not appear to be very effective against glioblastoma as the disease is still fatal. Our study aimed to explore new ways of diagnosing the disease to develop a treatment for this deadly disease. Method: This study included 40 individuals (20 glioblastoma multiforme 20 control groups). The blood samples were taken from the study groups, and biochemical analysis was performed. The groups were then compared for statistical significance. Results: Our study aimed to determine the relationship between enzymes, some parameters levels and glioblastoma multiforme. When compared to the control group, the levels of GSH-Px, SOD, CAT, AChE, and BChE were decreased in patients with GBM, and the levels of MDA caspase-3, BDNF, TNF alfa, and 8-OHdG were increased. Conclusion: The results noted here point out that Apoptosis, Cholinergic System Enzymes, and BDNF are good and accurate markers in Glioblastoma Multiforme to know of diagnosing the disease. Will make it possible to use characteristics seen in glioblastoma multiforme as indicators for assessing tumor aggressiveness, as well as to get a better understanding of Proteins that are involved in apoptosis as well as anti-apoptotic proteins, allowing for the creation of novel molecularly based treatments

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