Correlation Between AP-1 and PDL-1 Gene Countenance in Patients with Hodgkin?s Lymphoma
Abstract
Author(s): Siham Jasim Al-kaabi, Azhaar Jasim Mohsin
EBV infection induces the countenance of PD-L1, which limits antitumor T cell responses by different and potential mechanisms, Here we highlight the estimation level of the AP1 transcription factor that acts as a double-edged sword with both oncogenic and tumor suppressive activities by control on the level of PD-L1 checkpoints in EBV-infected Hodgkin lymphoma patients. To our knowledge, This is the first Iraqi research attempt to explore the detailed mechanism of PDL1 upregulation by AP1 which is induced by EBV infection. The research including of 23 cases Hodgkin lymphoma and 10 healthy control, after diagnosis of EBV VCA IgG by using ELISA assay. Our result indicated that, the level EBV VCA IgG was positive in (10 ) cases Hodgkin lymphoma at a percentage (43.47%) while the absence of this antibody in control group at a rate (0.0%). Also, the mean of PDL-1gene significantly higher in Hodgkin lymphoma compared with mean of PD-L1 (2.2±1.84) in control , as well as , the statistical significant increased value of AP-1 in Hodgkin lymphoma (1.37 ±0.94) compared with control (1.07±0.38) , addition in this research we found significant correlation between AP-1and PDL-1 in EBV + Hodgkin lymphoma patients with (r= 0.40) at significant (p ≤ 0.05) .
Share this article
Editors List
-
Ahmed Hussien Alshewered
University of Basrah College of Medicine, Iraq
-
Sudhakar Tummala
Department of Electronics and Communication Engineering SRM University – AP, Andhra Pradesh
-
Alphonse Laya
Supervisor of Biochemistry Lab and PhD. students of Faculty of Science, Department of Chemistry and Department of Chemis
-
Fava Maria Giovanna
- Manuprasad Avaronnan
Google Scholar citation report
Citations : 558
Onkologia i Radioterapia received 558 citations as per Google Scholar report
Onkologia i Radioterapia peer review process verified at publons
Indexed In
- Directory of Open Access Journals
- Scimago
- SCOPUS
- EBSCO A-Z
- MIAR
- Euro Pub
- Google Scholar
- Medical Project Poland
- PUBMED
- Cancer Index
- Gdansk University of Technology, Ministry Points 20