A dosimetric comparison between three dimensional conformal radiation therapy and volumetric-modulated arc therapy for medulloblastoma craniospinal irradiation

Abstract

Author(s): Abdelati Nourreddine, Maroua Benlemlih*, Abdelhak Maghous, Sanae El Mejjaoui, Tayeb Kebdani, Khalid Hassouni, Hanane EL kacemi, Noureddine Benjaafar and Rajaa Cherkaoui El Moursli

Aims: To compare Three-Dimensional Conformal Radiation Therapy (3DCRT) and Volumetric?Modulated Arc Therapy (VMAT) in Craniospinal Irradiation (CSI) with Posterior Fossa (PF) boost in children with Medulloblastoma (MB); dosimetry evaluation and comparison of both techniques with regard to target coverage and doses to organs at risk. Patients and Methods: Ten previously irradiated patients of MB treated with VMAT were retrieved and re?planned with 3D-CRT technique. Dosimetric comparison was done of the two plans. Prescription dose and normal tissue constraints were identical for both plans. Statistical Analysis Used: SPSS, version 25.0, statistical software package was used. For quantitative data, Anova and Post Hoc tests were applied to calculate the difference between two means. Results: The dose homogeneity was better in VMAT (0, 07) as compared to 3D-CRT (0, 12), with statistically significant difference (P=0.043). Conformity index was also better with VMAT technique (1, 08) than 3D-CRT (1, 34) with P=0.000. VMAT plan provided reduced mean dose and V20 to almost all organ at risk evaluated with a statistically significant difference. Conclusions: VMAT technique was able to improve homogeneity and conformity index, spare high dose to normal tissues

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